Day 1 
10 October 2011 (Monday)

12.00pm - 12.45pm   Registration
12.45pm - 1.00pm   Welcome address
Jean Paul Thiery, Convenor of TEMTIA-V
Institute of Molecular and Cell Biology, A*STAR, Singapore
   Session 1: Cell/Molecular Biology of EMT
Chairperson: Erik W. Thompson
St. Vincent's Institute, University of Melbourne, Australia.
1.00pm - 1.30pm   Shigeo Ohno, Yokohama City University, Japan
Epithelial cell polarity and the Par-aPKC complex
1.30pm - 2.00pm   Russ P. Carstens, University of Pennsylvania, USA
Defining the complex role of alternative splicing in the EMT
2.00pm - 2.30pm   Yeesim Khew-Goodall, Centre for Cancer Biology, SA Pathology, Australia
The miR-200 family of microRNAs in EMT
2.30pm - 2.50pm   Michael J. Murray, The University of Melbourne, Australia
Short talk: Identification of new EMT factors in the fly: an RNAi screen using Wing Eversion
2.50pm - 3.10pm   Carole LaBonne, Northwestern University, USA
Short talk: Coordinate regulation core EMT regulatory factors
3.10pm - 3.40pm   Afternoon Teabreak
   Session 2: Cell/Molecular Biology of EMT
Chairperson: David M. Epstein
OSI Pharmaceuticals, USA
3.40pm - 4.10pm   Hongquan Zhang, Peking University Health Science Center, China
Role of an integrin-interacting protein in the regulation of EMT in cancer and fibrosis
4.10pm - 4.40pm   Masatoshi Takeichi, Center for Developmental Biology, RIKEN Kobe, Japan
Adherens Junction Remodeling for Epithelial Migration and Closure
4.40pm - 5.10pm   Senthil K. Muthuswamy, University of Toronto, Canada
Short talk: Loss of cell polarity gene Par3 and metastasis
5.10pm - 5.30pm   Eric Theveneau, University College London, United Kingdom
Short talk: Lipid signalling links EMT and in vivo collective invasion via turnover of the cell-cell adhesion complex
5.30pm - 5.50pm   Jianmin Zhang, Roswell Park Cancer Institute, USA
Short talk: Pulsed expression of SNAI-1 implicates epigenetic silencing in epithelial-to-mesenchymal transition
   The EMBO Lecture & Betty Hay Oration
Chairperson: Jean Paul Thiery
Institute of Molecular and Cell Biology, A*STAR, Singapore
5.50pm - 6.50pm   Betty Hay Reception
6.50pm - 7.50pm   M. Angela Nieto, Instituto de Neurociencias (CSIC-UMH), Spain
The ins and outs of the EMT in health and disease
7.50pm - 9.20pm   Dinner & Poster session


Day 2 
11 October 2011 (Tuesday)

7.30am - 8.30am   Breakfast & dialogue session
   Session 3: Developmental EMT
Chairperson: Raymond Runyan
University of Arizona, USA
8.30am - 9.00am   Roberto Mayor, University College London, United Kingdom
Collective cell migration and EMT in the neural crest cells
9.00am - 9.30am   Shinichi Aizawa, Center for Developmental Biology, RIKEN Kobe, Japan
Post-transcriptional Regulation of Cadherin and Integrin by EPB41L5 in Epithelial-Mesenchymal Transition
9.30am - 9.50am   Ali Nawshad, The University of Nebraska Medical Center, USA
Short talk: TGFβ induced cell cycle arrest is the prerequisite for EMT in palate development
9.50am - 10.10am   Paul M. Kulesa, Stowers Institute for Medical Research, USA
Short talk: The Developmental Program of the Neural Crest Influences Malignant Melanoma to Drive Plasticity and Invasion
10.10am - 10.30am   Alpha Yap, Institute for Molecular Bioscience, Australia
Short talk: Dysregulation of the junctional actin cytoskeleton by HGF: a novel mechanism that acutely disrupts the epithelial zonula adherens
10.30am - 11.00am   Morning Teabreak
11.00am - 11.40am   Jenny Chang, Methodist Cancer Center, USA
Therapeutic Resistance of Tumour-initating Cells in Breast Cancer
   Session 4: Developmental EMT
Chairperson: Guojun Sheng
Center for Developmental Biology, RIKEN Kobe, Japan
11.40am - 12.10pm   José Luis de la Pompa, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain
Notch signaling in cardiac valve formation and disease
12.10pm - 12.40pm   David McClay, Duke University, USA
The gene regulatory network controlling EMT in sea urchin embryos
12.40pm - 1.00pm   Kathy K.H. Svoboda, Texas A&M Health Science Center, USA
Short talk: Ephrin reverse signaling promotes palate fusion through a PI3 Kinase dependent mechanism
1.00pm - 1.20pm   Yukiko Nakaya, Center for Developmental Biology, RIKEN Kobe, Japan
Short talk: CLASP-mediated microtubule anchoring promotes the cell-basement membrane interaction through dystroglycan in gastrulation EMT
1.20pm - 1.40pm   Kyra Campbell, Institute of Research in Biomedicine Barcelona, Spain
Short talk: Specific GATA factors act as conserved inducers of an epithelial-to-mesenchymal transition
1.40pm - 2.20pm   TEMTIA Annual General Meeting (TEMTIA Members only)
1.40pm - 3.30pm   Lunch & Poster session
Afternoon interaction and independent dinner


Day 3 
12 October 2011 (Wednesday)

7.30am - 8.30am   Breakfast & dialogue session
   Session 5: Mathematical Modeling of EMT and Invasion
Chairperson: Donald Newgreen
The Murdoch Childrens Research Institute, Australia
8.30am - 9.00am   Dawn Walker, University of Sheffield, United Kingdom
Computational Modelling of Cellular Communities – the effect of “Antisocial Cells”
9.00am - 9.30am   Muhammad H. Zaman, Boston University, USA
Multi-scale computation of EMT and collective cell motion in complex environments
9.30am - 9.50am   Ian Overton, MRC Human Genetics Unit Western General Hospital, United Kingdom
Short talk: Machine Learning Functional Networks to Infer EMT Genes
9.50am - 10.10am   Véronique Delmas, Institut Curie, France
Short talk: Biological and mathematical modeling : melanoblast proliferation and dermal to epidermal migration.
10.10am - 10.30am   J. Guy Lyons, University of Sydney, Australia
Short talk: A mathematical model to simulate cooperation between carcinoma cells that have undergone an EMT and those that remain well differentiated
10.30am - 11.00am   Morning Teabreak
   Session 6: Organ Fibrosis
Chairperson: Raghu Kalluri
Beth Israel Deaconess Medical Center, USA
11.00am - 11.30am   Valerie LeBleu, Harvard Medical School/Beth Israel Deaconess Medical Center, USA
The origin of myofibroblasts and the contribution of EMT in fibrosis
11.30am - 12.00pm   Zea Borok, University of Southern California, USA
EMT in pulmonary fibrosis: fact or fiction?
12.00pm - 12.20pm   Simon J. Conway, Indiana University School of Medicine, USA
Short talk: Lineage mapping cardiac fibroblasts during both normal homeostatic and pathological transformed states
12.20pm - 12.40pm   Raffaele Strippoli, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain
Short talk: Inhibition of transforming growth factor-activated kinase-1 (TAK-1) blocks and reverses epithelial to mesenchymal transition of mesothelial cells
12.40pm - 1.00pm   Yue-Lei Chen, Chinese Academy of Sciences (CAS), China
Short talk: Sorafenib Inhibits Transforming Growth Factor β1-Mediated Epithelial-Mesenchymal Transition and Apoptosis in Mouse Hepatocytes
1.00pm - 2.30pm   Lunch & Poster Session
   Session 7: Stem Cells and EMT
Chairperson: Pierre Savagner
Institut de Recherche en Cancérologie de Montpellier, France
2.30am - 3.00pm   Alain Puisieux, Centre de Recherche de Cancrologie de Lyon, France
Commitment to an EMT program catalyzes oncogene-induced cell transformation and initiates tumor initiation
3.00pm - 3.30pm   Gary L. Johnson, University of North Carolina, USA
Histone H2A/H2B Acetylation Regulated by MAP3K4 and CBP Controls Epithelial-Mesenchymal Transition in Trophoblast Stem Cells
3.30pm - 4.00pm   Thomas Brabletz, University of Freiburg, Germany
MicroRNAs, EMT and Cancer Stem Cells
4.00pm - 4.20pm   Aristidis Moustakas, Uppsala University, Sweden
Short talk: Regulation of cancer stem cell potential by the EMT inducers HMGA2 and Snail1
4.20pm - 4.40pm   Abdelkader SELMI, Institut de Recherche en Cancérologie de Montpellier, France
Short talk: Slug regulates stem/progenitor cell dynamics during mammary gland morphogenesis
4.40pm - 6.30pm   Afternoon Teabreak & Poster session
6.30pm   Depart to Banquet Venue (Transport is provided from conference venue)
7.00pm - 10.00pm   TEMTIA-V Banquet


Day 4 
13 October 2011 (Thursday)

   Session 8: Cancer and EMT
Chairperson: Hongquan Zhang
Peking University Health Science Center, China
8.30am - 9.00am   Owen Sansom, The Beatson Institute for Cancer Research, United Kingdom
Loss of p53 permits the development of invasive adenocarcinoma following Apc loss
9.00am - 9.30am   Raghu Kalluri, Beth Israel Deaconess Medical Center, USA
Pericyte Depletion Results in Hypoxia Associated Epithelial to Mesenchymal Transition and Metastasis Mediated by Met Signalling Pathway
9.30am - 9.50am   Yibin Kang, Princeton University, USA
Short talk: miR-200s enforces MET and influences Sec23a-dependent cancer cell secretome to promote metastatic colonization
9.50am - 10.10am   Sarah M. Dunlap, The University of Texas, USA
Short talk: Obesity Promotes Epithelial-To-Mesenchymal Transition and Tumor Progression in a Syngeneic Mouse Model of Claudin-Low Breast Cancer
10.10am - 10.30am   Kern Rei Chng, Genome Institute of Singapore, A*STAR, Singapore
Short talk: ERG, HDACs and EZH2 promote Epithelial Mesenchymal Transition in Prostate Cancers through Harmonizing AR Transcriptional Output
10.30am - 11.00am   Morning Teabreak
11.00am - 11.40am   Yoshiaki Ito, Cancer Science Institute of Singapore, NUS, Singapore
Runx3 protects gastric epithelial cells against EMT
   Session 9: : Cancer and EMT
Chairperson: Elizabeth Williams
Monash University, Australia
11.40am - 12.10pm   Klaus Pantel, University Medical Center Hamburg-Eppendorf, Germany
Micrometastases, circulating tumour cells and cancer dormancy
12.10pm - 12.30pm   Jihe Zhao, University of Central Florida, USA
Short talk: KLF8 Regulation of EMT and Breast Cancer Metastasis
12.30pm - 12.50pm   David I. Bellovin, Stanford University, USA
Short talk: A Transgenic Model of Twist1-Induced Metastasis is Associated with a Gene Signature that is Prognostic in Patients with Hepatocellular Carcinoma
12.50pm - 1.10pm   Ruby Yun-Ju Huang, Cancer Science Institute of Singapore, NUS, Singapore
Short talk: Epithelial-mesenchymal gene expression signature defines clinically relevant subtypes in epithelial ovarian cancer
1.10pm - 1.30pm   Geert Berx, Ghent University, Belgium
Short talk: Role of EMT-inducing Transcription Factors in Epithelial Cancer Progression
1.30pm - 3.00pm   Lunch & Poster Session
   Session 10 : Drug Discovery and EMT
Chairperson: M. Angela Nieto
Instituto de Neurociencias (CSIC-UMH), Spain
3.00pm - 3.30pm   David M. Epstein, OSI Pharmaceuticals, USA
Epithelial-mesenchymal transition in context of cancer therapy
3.30pm - 4.00pm   Patrick Humbert, Peter MacCallum Cancer Centre, Australia
Targeting Cell polarity and RAS/MAPK signalling in EMT and Epithelial tumour progression
4.00pm - 4.40pm   Sir David Lane, p53 Laboratory, A*STAR, Singapore
New antibodies to cMet
4.40pm - 5.00pm   Closing remarks & Award presentation ceremony
Erik W. Thompson, Co-convenor of TEMTIA-V
St. Vincent’s Institute, University of Melbourne, Australia