Affiliation: Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, USA
Guts & gastrulation: does a sequential EMT-MET cycle drive endoderm morphogenesis?
Anna-Katerina (Kat) Hadjantonakis is a Member of the Sloan Kettering Institute, of the Memorial Sloan Kettering Cancer Center, and a Professor at Cornell University, New York City, USA. She received a BSc in Biochemistry in 1990, and PhD in Molecular Genetics in 1995, from Imperial College, London. From 1996 to 2003 she undertook postdoctoral work at the Samuel Lunenfeld Research Institute, Toronto, and Columbia University, New York. The overarching goal of her research is to decipher mechanisms underlying the coordination of cell lineage specification and morphogenesis in mammals using embryos and embryo-derived stem cells as experimental platforms. Their focus is on some of the earliest decisions taken by cells in early embryos at the time of the first EMT and METs which correlate with the formation of mesoderm and endoderm germ layers at gastrulation. Quantitative analyses, involving single-cell resolution microscopic imaging and transcriptomics are a hallmark of the approach Kat and her collaborators take.