Sendurai A. Mani
Affiliation: Associate Professor | Department of Translational Molecular Pathology
Co-Director, Metastasis Research Center | Co-Director, Center for Stem Cell and Developmental Biology
MD Anderson Cancer Center
TITLE OF TALK: Targeting stress granules blocks sarcoma metastasis
Sendurai A. Mani is an Associate Professor in the Department of Translational Molecular Pathology at MD Anderson Cancer Center. He is also the co-director of the Metastasis Research Center as well as the Center for Stem Cell and Developmental Biology at MD Anderson Cancer Center. Mani’s laboratory uses various model systems, including cell lines, patient-derived tumor xenografts as well as mouse models to study the role of cancer stem cells (CSCs) in tumor progression. His original finding demonstrating the cancer cells acquire stem cell properties by activating latent embryonic epithelial-mesenchymal transition (EMT) program provided the foundation and explanation for the presence of plasticity within the tumor as well as the development of resistance to various treatments. Dr. Mani earned a Ph.D. from The Indian Institute of Science, Bangalore, India, and he did postdoctoral work with Dr. Robert A. Weinberg at the Whitehead Institute/Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA. He then joined the University of Texas MD Anderson Cancer Center, Houston, Texas as an Assistant Professor and has been promoted to Associate Professor and continuing his research at MD Anderson. Dr. Mani has received numerous prizes and awards for his research, including a Jimmy V foundation’s V-Scholar Award and The American Cancer Society M. Patricia Alexander Research Scholar award.